Hepatitis B immunity in hospital healthcare workers: targeting interventions for improved healthcare worker immunisation programmes

Miss Deborah Rhodes1,2, Professor Allen C. Cheng1,2

1Infection Prevention and Healthcare Epidemiology Unit – Alfred Health, Melbourne, Australia

2Monash University, Melbourne, Australia


Healthcare workers (HCWs) are at risk of Hepatitis B infection if not immune and exposed to blood and bodily fluids from those carrying Hepatitis B virus. Hepatitis B vaccination, followed by serological confirmation of immunity is recommended for those at occupational risk of exposure, however, many studies of HCWs show sub-optimal compliance.

A multi-centred, analytical cross-sectional study of public, private, metropolitan and rural hospitals is proposed. Using existing staff vaccination records as the data sources, specified inclusion and exclusion criteria will apply for sampling populations of category A HCWs to power the study at a probability of 80% and minimise type I error at 0.05, and evaluate the null hypothesis using an uncorrected chi-squared statistic.

This study aims to describe the characteristics of HCWs with and without documented evidence of Hepatitis B immunity, and determine the features of healthcare worker immunisation programmes with the highest prevalence rates of confirmed immunity.

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